A 1,100lb (500kg) US bomb was found and safely removed from a location along of the Sepon River in Quang Tri Province, which borders Laos, on Wednesday.
The unexploded Vietnam-War-era bomb was discovered by patrolling border guards after it was exposed by recent heavy rain.
Experts said the bomb could have been dropped by US Air Force during the Battle of Khe Sanh.
It was transported to a controlled demolition site, according to PeaceTrees Vietnam, a non-profit organization that works on on clearing unexploded ordnance (UXO) in central Vietnam.
It was founded in 1995 by Jerilyn Brusseau, sister of US pilot Dan Cheney who died during a combat in Vietnam, and her late husband Danaan Parry.
The organization has removed more than 73,000 dangerous weapons, including landmines, bombs, mortar shells, grenades, from the land and planted in their place a similar number of indigenous trees
An estimated 400,000 pieces of UXOs remain buried across 480,000 hectares of land in Quang Tri, which can be found in residential areas, gardens and even under the floors of houses.
Official statistics list more than 7,000 people, 31 percent of them children, as victims of UXO accidents in the province between 1975 and 2011.
Since the war ended in 1975, UXOs have killed 40,000 people nationwide and 60,000 injured, nearly half of them children below 16.